Principal Investigator:
Ian Gould
Other Investigators:
D. Nathwani and A. Seaton
Primary contact person:
Ian Gould
Primary Contact Email Address:
i.m.gould@abdn.ac.uk
Primary Country:
Scotland
Other Location Information:
Country wide
Project Description:
In response to a Clostridium difficile epidemic a nation-wide campaign was enacted to reduce use of the antibiotics most associated. The 4 C's — Cephalosporins, Clindamycin, Co-amoxiclav and Ciprofloxacin (fluoroquinolones).
A similar campaign is running in England and initiatives are now extending into primary care.
More about The 4 C's Project here Forums - Descriptions of National Programs.
Outcome / Result:
Physicians are bid reductions in use of these groups of drugs, to be replaced by gentamicin, amoxicillin and tetracyclines. Initial analysis suggests major reductions in DDDs per 1000 patient-days, C. difficile cases and and MRSA, although the data is often confounded by simultaneous infection control interventions.
